06 ( 7 809
نویسندگان
چکیده
* Corresponding Author: Fariba Khodagholi, PhD. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran – Iran Tel: 0098-21-22429768; Fax: 0098-21-22432047 E-mail: [email protected] Introduction: < = $$ " # various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand Y $ " X " X# $$ YY?_X3⁄4 $ X = $$ ! / & # & XY¿ YY?_X3⁄4 # " " $ $ Y YY?_X3⁄4 " $ ! Methods: / " $ # Y `^XÀ+ ` 3⁄4X# $ 3⁄4X > $ # X " " factors were determined using Western blot in different groups. Also cell viability was determined by the conventional MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) reduction assay and two staining involved # ? # ] $ + $ # " ! Results: Our results show that NS-398, a selective COX-2 inhibitor and 15d-PGJ2, " # YY?_X3⁄4 & " # $ " & $ # `^XÀ+ Nrf2 signaling pathway. Our data showed that 15d-PGJ2 and NS-398 induced ` # # " & & $ X 3⁄4X > & XY¿ `>X| `^XÀ+ ! / # " & $ # YY?_X3⁄4X " $ $ |[[ # YY?_X3⁄4 " ! Discussion: Thus we conclude that 15d-PGJ2 as well as NS-398 exert anti cell YY?_X3⁄4 " $ $ ! A B S T R A C T Article info: Received: 10 October 2011 First Revision: 25 October 2011 Accepted: 5 November 2011
منابع مشابه
The effects of pegylated interferon alpha 2b on bile-duct ligation induced liver fibrosis in rats
( ! ++ ! (+ ' + ( () %(* (+ ,* ( ./0 * * ) + , (! !1 ,! ) 2 ! ! 3 * ) * * ( + ) ( '!4 ( ' 5 ./ 6 ' + ( 7 809 ( ' : ./ 7 809 ( ' ; ! % 6 ' + ( 7 <09 ( ' = ! % 7 <09 * ( ' > ( ( ( ' 7 <01 ? + ( , ' : ->@ A B 0 ( ! -5 %/B 0 3 ! *% ! * ' ( ) 3 +( +( 3 !1 C % ( % % ! ) !! (D * ) ! !! ( * !+( % (3 + ( ,β ,β0 , ) ! 3 D % * + +( 3 !1 / ) ! * ! 3 ! * % (D * (! * E !!( (% F (%( % ! 1 ) ! (+ !! ( ,β ( % %...
متن کاملSegmenting Reliefs on Triangle Meshes
!8*&,0*/'& !"#$"%& '/# D)<#&? *7#< )$ >'/)6*7 )$<*70/)#7 96/ ,*/,67#7 7*8" '7 ',,&?)$% 4/'$<7 06 ,'82'%)$% '$< <#86/'0)$% ,6/8#&')$E$ 6/<#/ 06 #'7)&? ',,&? /#&)#97 06 3CF :6<#&7; )0 )7 690#$ <#7)/'4&# 06 /#>#/7#G#$%)$##/ ,/#>)6*7&? <#7)%$#< '$< :'$*9'80*/#< /#&)#97HF 78'$$#/7 8'$ %#$#/'0# 0/)'$%&# :#7"#7 9/6: 64I#807 D)0" /#&)#97J "6D#>#/; ,/#>)6*7 :#7" 7#%:#$0'0)6$ D6/2 "'7 $60 86$7)<#/#< 0"# ...
متن کاملSegmenting Reliefs on Triangle Meshes
!8*&,0*/'& !"#$"%& '/# D)<#&? *7#< )$ >'/)6*7 )$<*70/)#7 96/ ,*/,67#7 7*8" '7 ',,&?)$% 4/'$<7 06 ,'82'%)$% '$< <#86/'0)$% ,6/8#&')$E$ 6/<#/ 06 #'7)&? ',,&? /#&)#97 06 3CF :6<#&7; )0 )7 690#$ <#7)/'4&# 06 /#>#/7#G#$%)$##/ ,/#>)6*7&? <#7)%$#< '$< :'$*9'80*/#< /#&)#97HF 78'$$#/7 8'$ %#$#/'0# 0/)'$%&# :#7"#7 9/6: 64I#807 D)0" /#&)#97J "6D#>#/; ,/#>)6*7 :#7" 7#%:#$0'0)6$ D6/2 "'7 $60 86$7)<#/#< 0"# ...
متن کاملContents, Followers, and Retweets of the Centers for Disease Control and Prevention's Office of Advanced Molecular Detection (@CDC_AMD) Twitter Profile: Cross-Sectional Study.
BACKGROUND The Office of Advanced Molecular Detection (OAMD), Centers for Disease Control and Prevention (CDC), manages a Twitter profile (@CDC_AMD). To our knowledge, no prior study has analyzed a CDC Twitter handle's entire contents and all followers. OBJECTIVE This study aimed to describe the contents and followers of the Twitter profile @CDC_AMD and to assess if attaching photos or videos...
متن کاملPseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells
BACKGROUND P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated that P. aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells. Recently, a new investigational drug VX-809 has been shown to increase F508del-CFTR Cl secretion in human bronchial epithelial (HBE) cells, and, in comb...
متن کامل